Hypertrohpic Osteodystrophy can be found in large and giant breeds. It affects the young dogs that are growing and causes lameness in all four legs as well as extreme pain. Other symptoms of the condition can be the fever, inability to stand, loss of appetite and painful swelling of the lower limbs. It can be caused by a reaction to vaccinations in Weirmaraners specifically but the reaction may occur in Mastiffs and Great Danes. A theory on the cause of Hypertrohpic Osteodystrophy is a diet that consists of high calcium and protein levels. The outcome for the puppy can range from full recovery, permanent disability and in some cases death. Due to the pain that the puppy undergoes, many owner elect to euthanize but it is important to remember that the outcome for recovery is reasonably good. Treatment of Hypertrohpic Osteodystrophy is a treatment of analgesic medications, Hydrocodone, antibiotics and the reduction of calcium in the puppy’s diet. Pain relief is an important treatment and in the case of severe bone changes, surgery may be necessary.