An inherited abnormality that affects the white blood cells ability to fight infection. This disease impairs the immune system and is found in Irish Setters. Dogs who have this disease will suffer from immunological complications and reoccurring infections. Breeders are currently trying to remove Canine Leukocyte from their breeding lines and there is a DNA test that can be done to show that a dog is free of the gene. It is important to ask your potential breeder if their dogs have been screened for CLAD.