Neapolitan Mastiffs are generally healthy, but like all breeds, they can be subject to certain health conditions. Not all Neos will get any or all of these diseases, but it's important to be aware of them if you're considering this breed.

Hip Dysplasia

This is a heritable condition in which the thighbone doesn't fit snugly into the hip joint. Some dogs show pain and lameness on one or both rear legs, but you may not notice any signs of discomfort in a dog with hip dysplasia. As the dog ages, arthritis can develop. X-ray screening for hip dysplasia is done by the Orthopedic Foundation for Animals or the University of Pennsylvania Hip Improvement Program (PennHIP). Dogs with hip dysplasia should not be bred. Hip dysplasia is hereditary, but it can be worsened by environmental factors, such as rapid growth from a high-calorie diet or injuries incurred from jumping or falling on slick floors.

Elbow Dysplasia

This is a heritable condition common to large-breed dogs. It's thought to be caused by different growth rates of the three bones that make up the dog's elbow, causing joint laxity. This can lead to painful lameness. Your vet may recommend surgery to correct the problem, or medication to control the pain.

Cardiomyopathy

This heart condition occurs when the heart muscle becomes very thin and is unable to contract normally. Because the heart must work harder, it becomes enlarged. Dogs with this disease have an abnormal heart rhythm and show signs of heart failure, including weakness, loss of appetite, weight loss, depression, collapse, difficulty breathing, a soft cough, and an enlarged abdomen. There is no cure, but rest, diet, and medication can help for a time.

Cherry Eye

This condition occurs when the gland located in the dog's third eyelid (known as the nictitating membrane) bulges out. It looks like a reddened mass at the inner corner of the eye. Cherry eye can be repaired surgically.

Cleft Palate

The palate is the roof of the mouth and separates the nasal and oral cavities. It is made up of two parts, hard and soft. A cleft palate has a slit that runs bilaterally or unilaterally and can range in size from a small hole to a large slit. A cleft palate can affect both the hard and soft palate separately and together and may cause a cleft lip.

Puppies can be born with cleft palates, or a cleft palate can occur from an injury. Cleft palates are fairly common in dogs, but many puppies born with a cleft palate do not survive or are euthanized by the breeder. The only treatment for a cleft palate is surgery to close the hole, although not all dogs with a cleft palate require the surgery. It is important to get a diagnosis and treatment recommendation from your veterinarian.

Demodicosis

All dogs carry a little passenger called a demodex mite. The mother dog passes this mite to her pups in their first few days of life. The mite can't be passed to humans or other dogs; only the mother passes mites to her pups. Demodex mites live in hair follicles and usually don't cause any problems. If your Neo has a weakened or compromised immune system, however, he can develop demodectic mange.

Demodectic mange, also called demodicosis, can be localized or generalized. In the localized form, patches of red, scaly skin with hair loss appears on the head, neck and forelegs. It's thought of as a puppy disease, and often clears up on its own. Even so, you should take your dog to the vet because it can turn into the generalized form of demodectic mange.

Generalized demodectic mange covers the entire body and affects older puppies and young adult dogs. The dog develops patchy skin, bald spots, and skin infections all over the body. The American Academy of Veterinary Dermatology recommends neutering or spaying all dogs that develop generalized demodectic mange because there is a genetic link.

Fold Dermatitis

A skin infection caused by moisture trapped in the folds of the skin. The signs of fold dermatitis are redness, sores, and odor. The dog can be affected on the tail, face, lips, vulvar folds, or any other wrinkled area. Mild cases of fold dermatitis are usually treated with topical ointments or antibiotics, but severe cases may require surgical removal of the folds or amputation of the tail in the case of fold dermatitis on the tail. Keep your Neo's wrinkles clean and dry to prevent this problem.

Find a good breeder

If you're buying a puppy, find a good breeder who will show you health clearances for both your puppy's parents. Health clearances prove that a dog's been tested for and cleared of a particular condition.

In Neos, you should expect to see health clearances from the Orthopedic Foundation for Animals for hips, elbows, and heart, as well as certification from the Canine Eye Registry Foundation (CERF) that the eyes are normal.

Because some health problems don't appear until a dog reaches full maturity, health clearances aren't issued to dogs younger than two years old. Look for a breeder who doesn't breed her dogs until they're two or three years old.

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